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KMID : 0381219950270010021
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Journal of RIMSK
1995 Volume.27 No. 1 p.21 ~ p.27
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Serum Lipoprotein(a) Concentrations in Patients with Diabetic Nephropathy
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정현경
김재택/김광석/오연상/신순현
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Abstract
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Non-insulin-dependent diabetes mellitus patients have about fiveflod increased risk of atherosclerotic coronary haert disease and early mortality relative to nondiabetic subjects, particularly if they have persistent proteinuria. This excess risk
is
explained only partially by increased levels of standard risk factors. Lipoprotein(a) is hybrid of low density lipoprotein(LDL) and a specific plasminogen-like glycoprotein apo(a), and thought thought that potentially have atherogenic properties.
This
study was designed to compare the plasma lipoprotein(a) concentration on NIDDM patients with and without microalbuminuria and normal controls. 38 NLDDM patients; 1l no microalbuminuria, 16 microalbuminuria, 11 macroalbuminuria and 12 normal
controls
were included. Serum Lp(a) concentrations were measured by ELISA method.
Median plasma Lp(a) concentration was 7,5 mg/dl in normal control, 10.0 mg/dl in no albuminuria, 13.5 mg/dl in microalbuminuria and 30 mg/dl in macroalnbuminuria. There was no statistically significant differences between groups except normal
control vs
macroalbuminuria group (p<0.05). Otherwise there were significantly increased rate of hypertension and plasma concentration of the fibrinogen.
Our study revealed no statistically significant elevation in plasma concentration of lipoprotein(a) according to the severity of the diabetic nephropathy, but number were small.
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KEYWORD
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